THE DONG RESEARCH GROUP

at Peking University School of Pharmaceutical Sciences

the dong research group

Independent research

44. Design and Structural Elucidation of Glycopeptide Fibrils: Emulating Glycosaminoglycan Functions for Biomedical Applications

J. Am. Chem. Soc. 2025, 147(23):20132–20143.
Wencheng Xia, Zhongxin Xu, Hui Dong, Shengnan Zhang, Changdong He, Dan Li, Bo Sun, Bin Dai, Suwei Dong* & Cong Liu*
43. An O-glycopeptide participates in the formation of distinct Aβ42 fibril structures and attenuates Aβ42 neurotoxicity

Nat. Commun., 16, 5815 (2025).
Qijia Wei, Dangliang Liu, Wencheng Xia, Fengzhang Wang, Lu Huang, Jun Zhang, Xiaoya Wang, Zhongxin Xu, Changdong He, Wenzhe Li, Xiaomeng Shi, Chu Wang, Yuan Liu*, Cong Liu* & Suwei Dong*
42. Glucuronidase-Instructed Glycopeptide Self-Assembly for Selective Killing of Cancer Cells through Lysosomal Membrane Permeabilization

Angew. Chem. Int. Ed. 2025,
Zhongxin Xu, Changdong He, Xinyu Li, Lu Huang, Bo Cheng, Suwei Dong*
41. Investigation of N-Glycan Functions in Receptor for Advanced Glycation End Products V Domain through Chemical Glycoprotein Synthesis

J. Am. Chem. Soc. 2024, 146(27):18270-18280.
Weidong Dong, Xingyue Yang, Xinyu Li, Sheng Wei, Chuanjing An, Jun Zhang, Xiaomeng Shi, and Suwei Dong*
40. Exploring the Light-Emitting Agents in Renilla Luciferases by an Effective QM/MM Approach

J. Am. Chem. Soc. 2024, 146, 20, 13875–13885
Ashim Nandi, Aoxuan Zhang, Zhen Tao Chu, Wen Jun Xie, Zhongxin Xu, Suwei Dong, and Arieh Warshel*
39. Recent advances in chemical protein synthesis: method developments and biological applications

SCC (2024) 67, 1060–1096.
Suwei Dong, Ji-Shen Zheng, Yiming Li, Huan Wang, Gong Chen, Yongxiang Chen, Gemin Fang, Jun Guo, Chunmao He, Honggang Hu, Xuechen Li, Yanmei Li, Zigang Li, Man Pan, Shan Tang, Changlin Tian, Ping Wang, Bian Wu, Chuanliu Wu, Junfeng Zhao, Lei Liu*
38. A co-assembly platform engaging macrophage scavenger receptor A for lysosome-targeting protein degradation

Nat Commun 15, 1663 (2024).
Qian Wang, Xingyue Yang, Ruixin Yuan, Ao Shen, Pushu Wang, Haoting Li, Jun Zhang, Chao Tian, Zhujun Jiang, Wenzhe Li & Suwei Dong*
37. In-Bridge Stereochemistry: A Determinant of Stapled Peptide Conformation and Activity

ChemBioChem 2024, e202300747.
Jingyi Zhang, Prof. Dr. Suwei Dong*
36. Enhancing luciferase activity and stability through generative modeling of natural enzyme sequences

Proc Natl Acad Sci U S A. 2023;120(48):e2312848120.
Wenjun Xie, Dangliang Liu, Xiaoya Wang, Aoxuan Zhang, Qijia Wei, Ashim Nandi, Suwei Dong* and Arieh Warshel*
35. Facile Preparation of Carbohydrate-Containing Adjuvants Based on Self-Assembling Glycopeptide Conjugates

Angew. Chem. Int. Ed. 2024, 63, e202309140.
Biao Wang, Sijin Liu, Haoting Li, Weidong Dong, Haiyun Liu, Jun Zhang, Chao Tian, Suwei Dong*
34. DNA damage-induced YTHDC1 O-GlcNAcylation promotes homologous recombination by enhancing m6A binding

Fundamental Research 2023.
Mengyao Li , Jie Li , Yibo Wang, Jianxin Zhao, Aiyun Yuan, Weidong Dong, Linlin Kong,Suwei Dong, Weijie Qin, Yun-Gui Yang, Xiaohui Wang Chen Wu, Jing Li
33. Discovery of Itaconate-Mediated Lysine Acylation

J. Am. Chem. Soc. 2023, 145, 23, 12673–12681
Dongyang Liu, Weidi Xiao, Haoting Li, Yanling Zhang, Shouli Yuan, Chengxi Li, Suwei Dong*, and Chu Wang*
32. Profiling the metabolome of uterine fluid for early detection of ovarian cancer

Cell Rep Med. 2023;4(6):101061.
Pan Wang, Jihong Ma, Wenjing Li, Qilong Wang, Yinan Xiao, Yuening Jiang, Xiaoyang Gu, Yu Wu, Suwei Dong, Hongyan Guo*, Mo Li *
31. Visible light cross-linking and bioactive peptides loaded integrated hydrogel with sequential release to accelerate wound healing complicated by bacterial infection

Nano Res. 17, 1737–1747 (2024).
Guiyan Wang, Ning Yuan, Jun Zhang, Man Qin, Suwei Dong* & Yuguang Wang*
30. An efficient metal-free desulfurization strategy promoted by Togni-II reagent

Chem. Commun., 2023,59, 6513-6516
Jun Zhang, Haiyun Liu,Shuang Teng,Zhiwen Laiao, Lingkui Meng, Qian Wan, and Suwei Dong*
29. Fine Tuning the Properties of Stapled Peptides by Stereogenic α-Amino Acid Bridges

Chem. Eur. J. 2023, 29, e202203624.
Qian Wang, Fengzhang Wang, Rui Li, Pushu Wang, Ruixin Yuan, Dangliang Liu, Yuan Liu, Prof. Yi Luan, Prof. Chu Wang*, Prof. Suwei Dong*
28. Synthesis, antitumor activities and functional mechanism of purine derivatives harboring phenyl moieties through three carbon bridges

Med Chem Res 32, 749–763 (2023).
Chao Tian, Yifei Chen, Meng Wang, Jing Cong, Hao Li, Suwei Dong, Xiaowei Wang, Junyi Liu & Zhili Zhang
27. Discovery of endosomalytic cell-penetrating peptides based on bacterial membrane-targeting sequences

Bioorganic Chemistry. 2023, 134, 106424
Chuanjing An, Sheng Wei, Yuankun Dao, Xiaoya Wang, Weidong Dong, Xue You, Chao Tian, Zhili Zhang, Suwei Dong*
26. PDTAC: Targeted Photodegradation of GPX4 Triggers Ferroptosis and Potent Antitumor Immunity

J. Med. Chem. 2022, 65, 18, 12176–12187
Sijin Liu, Xi Zhao, Sufang Shui, Biao Wang, Yingxian Cui, Suwei Dong, Tairan Yuwen, and Guoquan Liu*
25. Exploiting Complex-Type N-Glycan to Improve the in Vivo Stability of Bioactive Peptides

CCS Chemistry 2023, 5 (7), 1623-1634.
Qijia Wei†, Jun Zhang†, Yuankun Dao, Mengliang Ye, Dangliang Liu, Weidong Dong, Ning Yuan, Hongxing Li, Chunli Song, Mo Li, Xiaomeng Shi* and Suwei Dong*
24. N-Glycan Engineering: Constructing the N-GlcNAc Stump

ChemBioChem 2023, 24, e202200388.
Qifan Wu, Prof. Dr. Suwei Dong*, Prof. Dr. Weimin Xuan*
23. Vascular Endothelial Growth Factor Mimetic Peptide and Parathyroid Hormone (1-34) Delivered via a Blue-Light-Curable Hydrogel Synergistically Accelerate Bone Regeneration

ACS Appl. Mater. Interfaces 2022, 14, 31, 35319–35332
Guiyan Wang, Ning Yuan, Ningyu Li, Qijia Wei, Yuping Qian, Jun Zhang, Man Qin, Yuguang Wang*, and Suwei Dong*
22. Protection-Free Site-Directed Peptide or Protein S-Glycosylation and Its Application in the Glycosylation of Glucagon-like Peptide 1

CCS Chemistry 2022, 4, 6,1930-1937
Gefei Li, Yuankun Dao, Juan Mo, Suwei Dong, Shin-ichiro Shoda and Xin-Shan Ye*
21. O-GlcNAcylation modulates liquid–liquid phase separation of SynGAP/PSD-95

Nat. Chem. 14, 831–840 (2022).
Pinou Lv, Yifei Du, Changdong He, Luxin Peng, Xinyue Zhou, Yi Wan, Menglong Zeng, Wen Zhou, Peng Zou, Chenjian Li, Mingjie Zhang, Suwei Dong* and Xing Chen*
20. Site-Specific Protein Modification with Reducing Carbohydrates

Angew. Chem. Int. Ed. 2022, 61, e202116545
Qifan Wu, Weidong Dong, Hui Miao, Qian Wang, Suwei Dong, Weimin Xuan*
19. Synthesis of PNGase-resistant N-glycopeptide containing an α-anomeric glycosidic linkage

J Carbohydr Chem 40:7-9, 518-534
Yuankun Dao, Weidong Dong, Jun Zhang & Suwei Dong*
18. Rational Design of Self-Assembled Mitochondria-Targeting Lytic Peptide Conjugates with Enhanced Tumor Selectivity

Chem. Eur. J. 2022, 28, e202103517.
Sijin Liu, Biao Wang, Yina Sheng, Dr. Suwei Dong* ,Dr. Guoquan Liu*
17. A novel amphiphilic motif at the C-terminus of FtsZ1 facilitates chloroplast division

The Plant Cell 2021, 34 (1), 419-432.
Xiaomin Liu, Jinjie An, Lulu Wang, Qingqing Sun, Chuanjing An, Bibo Wu, Conghao Hong, Xiaoya Wang, Suwei Dong, Junhua Guo, Yue Feng, Hongbo Gao*
16. O-Glycosylation Induces Amyloid-β To Form New Fibril Polymorphs Vulnerable for Degradation

J. Am. Chem. Soc. 2021, 143, 48, 20216–20223
Dangliang Liu, Qijia Wei, Wencheng Xia, Changdong He, Qikai Zhang, Lu Huang, Xiaoya Wang, Yunpeng Sun, Yeyang Ma, Xiaohui Zhang, Yuan Wang, Xiaomeng Shi, Cong Liu*, and Suwei Dong*
15. Functional Characterization and Crystal Structure of the Bifunctional Thioesterase Catalyzing Epimerization and Cyclization in Skyllamycin Biosynthesis

ACS Catal. 2021, 11, 18, 11733–11741
Jiahui Yu, Juan Song, Changbiao Chi, Tan Liu, Tongtong Geng, Zonghui Cai, Weidong Dong, Cheng Shi, Xueyang Ma, Zhongyi Zhang, Xiaojie Ma, Baiying Xing, Hongwei Jin, Liangren Zhang, Suwei Dong, Donghui Yang, and Ming Ma*
14. Facile Generation of Strained Peptidyl Thiolactones from Hydrazides and Its Application in Assembling MUC-1 VNTR Oligomers

Chin. J. Chem., 39: 2509-2516
Yuankun Dao,Biao Wang,Weidong Dong,Jun Zhang,Chao Zhong,Zhili Zhang,Suwei Dong*
13. Probing N-Glycan Functions in Human Interleukin-17A Based on Chemically Synthesized Homogeneous Glycoforms

J. Am. Chem. Soc. 2021, 143, 7, 2846–2856
Hongxing Li, Jun Zhang, Chuanjing An, and Suwei Dong*
12. Glycopeptide Self-Assembly Modulated by Glycan Stereochemistry through Glycan−Aromatic Interactions

J. Am. Chem. Soc. 2020, 142, 40, 17015–17023
Changdong He, Shuang Wu, Dangliang Liu, Changbiao Chi, Weilin Zhang, Ming Ma, Luhua Lai, and Suwei Dong*
11. Synthesis and biological evaluation of a lipopeptide-based methamphetamine vaccine

Chin. Chem. Lett. 2021, 32, 1575–1579
Liao Fan,Hanxuan Wang,Yuankun Dao,Kai Yuan,Jiazhen Lu,Jie Shi,Ying Han,Suwei Dong,Lin Lu
10. Self‐Assembling Glycopeptide Conjugate as a Versatile Platform for Mimicking Complex Polysaccharides

Adv. Sci. 2020, 7, 2001264.
Hanxuan Wang, Zhichao Liu, Chuanjing An, Haoting Li, Fanlei Hu, Suwei Dong*
9. Chemical Syntheses and Biological Evaluation of CXCL14 and Its Site-Selectively Modified Methionine Sulfoxide-Containing Derivatives

J. Org. Chem. 2020, 85, 3, 1740–1747
Zonghui Cai, Qijia Wei, Xiujuan Li, Yi Luan*, and Suwei Dong*
8. α-Selective Lysine Ligation and Application in Chemical Synthesis of Interferon Gamma

Org. Lett. 2019, 21, 3265–3270
Yuankun Dao, Lin Han, Hanxuan Wang, and Suwei Dong*
7. β-Glucan as an immune activator and a carrier in the construction of a synthetic MUC1 vaccine

Chem. Commun. 2019, 55, 253.
Hanxuan Wang, Bing Yang, Yinglu Wang, Fen Liu, Alberto Ferna ´ndez-Tejada * and Suwei Dong *
6. Cypemycin Decarboxylase CypD Is Not Responsible for Aminovinyl–Cysteine (AviCys) Ring Formation

Org. Lett. 2018, 20, 23, 7670–7673
Wei Ding, Ning Yuan, Dhanaraju Mandalapu, Tianlu Mo, Suwei Dong*, and Qi Zhang*
5. Shape linear peptides into rigid rings: a sp3 C–H arylation approach to cyclophane-braced peptide macrocycles

Sci. China Chem. 2018, 61, 1477.
Yuankun Dao, Suwei Dong*
4. Traceless β-mercaptan-assisted activation of valinyl benzimidazolinones in peptide ligations

Chem. Sci. 2018, 9, 1940.
Yinglu Wang, Lin Han, Ning Yuan, Hanxuan Wang, Hongxing Li, Jinrong Liu, Huan Chen, Qiang Zhang* and Suwei Dong*
3. Synthetic studies toward human interleukin-5

Chin. Chem. Lett. 2018, 29, 1131.
Jinrong Liu, Suwei Dong*
2. Recent advances in the preparation of Fmoc-SPPS-based peptide thioester and its surrogates for NCL-type reactions

Sci. China Chem. 2017, 60, 201.
Hongxing Li , Suwei Dong*
1. Internal Activation of Peptidyl Prolyl Thioesters in Native Chemical Ligation

J. Am. Chem. Soc. 2016, 138, 4890.
Yue Gui, Lingqi Qiu, Yaohao Li, Hongxing Li, and Suwei Dong*

Post-doctoral，graduate，and undergraduate research

13. Erythropoietin Derived by Chemical Synthesis

Science, 2013, 342, 1357-1360.
Ping Wang, Suwei Dong, Jae-Hung Shieh, Elizabeth Peguero, Ronald Hendrickson, Malcolm A. S. Moore, Samuel J. Danishefsky*
12. The Winding Pathway to Erythropoietin Along the Chemistry–Biology Frontier: A Success At Last

Angew. Chem. Int. Ed. 2013, 52, 7646-7665.
Rebecca M. Wilson, Dr. Suwei Dong, Dr. Ping Wang, Prof. Samuel J. Danishefsky*
11. Chemistry as an Expanding Resource in Protein Science: Fully Synthetic and Fully Active Human Parathyroid Hormone‐Related Protein (1– 141)

Angew. Chem. Int. Ed. 2012, 51, 12263-12267.
Dr. Jianfeng Li, Dr. Suwei Dong, Dr. Steven D. Townsend, Dr. Thomas Dean, Prof. Thomas J. Gardella, Prof. Samuel J. Danishefsky*
10. At Last: Erythropoietin as a Single Glycoform

Angew. Chem. Int. Ed. 2012, 51, 11576-11584.
Dr. Ping Wang, Dr. Suwei Dong, Dr. John A. Brailsford, Dr. Karthik Iyer, Dr. Steven D. Townsend, Dr. Qiang Zhang, Dr. Ronald C. Hendrickson, Dr. JaeHung S
9. Synthesis of Chamaecypanone C Analogues from in Situ-Generated Cyclopentadienones and Their Biological Evaluation

J. Am. Chem. Soc. 2012, 134, 19782-19787.
Suwei Dong, Tian Qin, Ernest Hamel, John A. Beutler, and John A. Porco, Jr.*
8. Engineering of Therapeutic Polypeptides through Chemical Synthesis: Early Lessons from Human Parathyroid Hormone and Analogues

J. Am. Chem. Soc. 2012, 134, 15122-15129.
Suwei Dong, Shiying Shang, Jianfeng Li, Zhongping Tan, Thomas Dean, Akira Maeda, Thomas J. Gardella, and Samuel J. Danishefsky*
7. Advances in Proline Ligation

J. Am. Chem. Soc. 2012, 134, 3912-3916.
Steven D. Townsend, Zhongping Tan, Suwei Dong, Shiying Shang, John A. Brailsford, and Samuel J. Danishefsky*
6. Microwave-Based Reaction Screening: Tandem Retro-Diels–Alder/Diels–Alder Cycloadditions of o-Quinol Dimers

J. Org. Chem. 2011, 76, 8944-8954.
Suwei Dong, Katharine J. Cahill, Moon-Il Kang, Nancy H. Colburn, Curtis J. Henrich, Jennifer A. Wilson, John A. Beutler, Richard P. Johnson*, and John A. Porco, Jr.
5. Toward Homogeneous Erythropoietin: Application of Metal‐Free Dethiylation in the Chemical Synthesis of the Ala79‐Arg166 Glycopeptide Domain

Israel J. Chem. 2011, 51, 968-976.
Suwei Dong, Shiying Shang, Zhongping Tan, Samuel J. Danishefsky*
4. An Advance in Proline Ligation

J. Am. Chem. Soc. 2011, 133, 10784-10786.
Shiying Shang, Zhongping Tan, Suwei Dong, and Samuel J. Danishefsky*
3. Enantioselective Synthesis of (+)‐Chamaecypanone C: A Novel Microtubule Inhibitor

Angew. Chem. Int. Ed. 2009, 48, 1494-1497.
Suwei Dong, Ernest Hamel, Ruoli Bai, David G. Covell, John A. Beutler, and John A. Porco Jr.
2. Enantioselective Synthesis of Bicyclo[2.2.2]octenones Using a Copper-Mediated Oxidative Dearomatization/[4 + 2] Dimerization Cascade

J. Am. Chem. Soc. 2008, 130, 2738-2739.
Suwei Dong, Jianglong Zhu, and John A. Porco*
1. Synthesis of oxygen-containing heterocyclic compounds based on the intramolecular O–H insertion and Wolff rearrangement of α-diazocarbonyl compounds

Tetrahedron Lett. 2006, 47, 4537-4540.
Mingyi Liao, Suwei Dong, Guisheng Deng, Jianbo Wang*

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