at Peking University School of Pharmaceutical Sciences
​​​​the dong research group
13. Synthesis and biological evaluation of a lipopeptide-based methamphetamine vaccine
Chin. Chem. Lett. Volume 32, Issue 4,2021
Liao Fan,Hanxuan Wang,Yuankun Dao,Kai Yuan,Jiazhen Lu,Jie Shi,Ying Han,Suwei Dong,Lin Lu

We describe an application of carrier protein-free strategy in constructing a fully synthetic methamphetamine (METH) vaccine that contains three components: Toll-like receptor 2 ligand, Th2 epitope, and METH hapten. The immunological evaluation in mice revealed high titers of METH-specific antibodies induced by the construct and the activation of humoral immunity that would be beneficial for neutralization and clearance of the METH molecule. Behavioral experiments indicated that the synthetic vaccine attenuated the acquisition of METH-induced conditioned place preference and inhibited the initiation and expression of METH-induced locomotor sensitization. These results demonstrate that the lipopeptide-based vaccine has invoked an immune response and showed the potential of preventing the rewarding and psychoactive effects of METH.