at Peking University School of Pharmaceutical Sciences
​​​​the dong research group
2. Enantioselective Synthesis of Bicyclo[2.2.2]octenones Using a Copper-Mediated Oxidative Dearomatization/[4 + 2] Dimerization Cascade
J. Am. Chem. Soc. 2008, 130, 2738-2739.
Suwei Dong, Jianglong Zhu, and John A. Porco*

An enantioselective approach to bicyclo[2.2.2]octenone structures utilizing a copper-mediated asymmetric oxidative dearomatization/[4 + 2] dimerization cascade is described. The total synthesis and absolute stereochemistry reassignment of (+)-aquaticol has been achieved using the methodology.