11. Chemistry as an Expanding Resource in Protein Science: Fully Synthetic and Fully Active Human Parathyroid Hormone‐Related Protein (1– 141)
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作者: Dr. Jianfeng Li, Dr. Suwei Dong, Dr. Steven D. Townsend, Dr. Thomas Dean, Prof. Thomas J. Gardella, Prof. Samuel J. Danishefsky*
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发布时间: 2012-12-04
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Angew. Chem. Int. Ed. 2012, 51, 12263-12267.
Dr. Jianfeng Li, Dr. Suwei Dong, Dr. Steven D. Townsend, Dr. Thomas Dean, Prof. Thomas J. Gardella, Prof. Samuel J. Danishefsky*
The convergent synthesis of human parathyroid hormone‐related protein (hPTHrP, see scheme) has been accomplished through iterative peptide ligations followed by global metal‐free dethiylation. The biological activity of synthetic PTHrP has been demonstrated.
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