at Peking University School of Pharmaceutical Sciences
​​​​the dong research group
7. Advances in Proline Ligation
J. Am. Chem. Soc. 2012, 134, 3912-3916.
Steven D. Townsend, Zhongping Tan, Suwei Dong, Shiying Shang, John A. Brailsford, and Samuel J. Danishefsky*

Application of native chemical ligation logic to the case of an N-terminal proline is described. Two approaches were studied. One involved incorporation of a 3R-substituted thiyl-proline derivative. Improved results were obtained from a 3R-substituted selenol function, incorporated in the context of an oxidized dimer.